Hypercalcemia and parathyroid hormone-related peptide expression in a dog with thyroid carcinoma and histiocytic sarcoma

Vet Clin Pathol. 2015 Jun;44(2):249-52. doi: 10.1111/vcp.12244. Epub 2015 Feb 23.


A 9.5-year-old, male castrated Walker Hound was presented for evaluation of progressive weakness, anorexia, and weight loss. Imaging revealed multiple abdominal and thoracic masses and ascites; fine-needle aspirates of mesenteric and splenic masses confirmed malignancy, most likely histiocytic sarcoma. Laboratory analyses revealed increased ionized calcium and parathyroid hormone-related peptide (PTH-rP) concentrations, and concurrent low-normal parathyroid hormone concentration, consistent with humoral hypercalcemia of malignancy. Necropsy was performed after euthanasia. The dog had disseminated histiocytic sarcoma, including sarcomatosis, as well as bilateral thyroid carcinoma. PTH-rP immunostaining was positive in the thyroid carcinoma but negative in the histiocytic neoplasm. These results suggest that thyroid carcinoma-associated hypercalcemia can be caused by tumor secretion of PTH-rP.

Keywords: Calcium; canine; paraneoplastic.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Blood Cell Count / veterinary
  • Carcinoma / metabolism
  • Carcinoma / pathology
  • Carcinoma / veterinary*
  • Dog Diseases / metabolism*
  • Dog Diseases / pathology
  • Dogs
  • Gene Expression Regulation, Neoplastic
  • Histiocytic Sarcoma / metabolism
  • Histiocytic Sarcoma / pathology
  • Histiocytic Sarcoma / veterinary*
  • Hypercalcemia / genetics
  • Hypercalcemia / metabolism*
  • Male
  • Parathyroid Hormone-Related Protein / genetics
  • Parathyroid Hormone-Related Protein / metabolism*
  • Thyroid Neoplasms / metabolism
  • Thyroid Neoplasms / pathology
  • Thyroid Neoplasms / veterinary*


  • Parathyroid Hormone-Related Protein