Successful treatment of hepatitis E virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin

Transpl Infect Dis. 2015 Apr;17(2):279-83. doi: 10.1111/tid.12353. Epub 2015 Feb 24.


Hepatitis E virus genotype-3 (HEV3) infection can cause chronic hepatitis in immunosuppressed patients and induce extra-hepatic manifestations, such as neurological symptoms, kidney injuries, and immune-mediated thrombocytopenia. Very few cases of HEV-induced kidney manifestations have been reported. Herein, we report, for the first time, a case of de novo membranoproliferative glomerulonephritis that occurred in a kidney transplant patient who developed a chronic HEV3 infection, which was successfully treated with ribavirin.

Keywords: de novo glomerulopathy; hepatitis E virus; kidney transplantation; membranoproliferative glomerulonephritis; ribavirin.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Cryoglobulinemia / drug therapy*
  • Cryoglobulinemia / etiology
  • Cryoglobulinemia / virology
  • Glomerulonephritis, Membranoproliferative / drug therapy*
  • Glomerulonephritis, Membranoproliferative / etiology
  • Glomerulonephritis, Membranoproliferative / virology
  • Graft Rejection / prevention & control*
  • Hepatitis E / drug therapy*
  • Hepatitis E virus
  • Humans
  • Immunocompromised Host*
  • Immunosuppressive Agents / adverse effects*
  • Kidney Transplantation*
  • Male
  • Middle Aged
  • Nephritis, Hereditary / surgery
  • Ribavirin / therapeutic use*
  • Transplant Recipients
  • Treatment Outcome


  • Antiviral Agents
  • Immunosuppressive Agents
  • Ribavirin