Relation between vitamin D status and nonalcoholic fatty liver disease in children

J Pediatr Gastroenterol Nutr. 2015 Mar;60(3):396-404. doi: 10.1097/MPG.0000000000000598.


Objectives: In adults, vitamin D deficiency is common in patients with nonalcoholic fatty liver disease (NAFLD) and has been associated with the severity of histology. There are known differences between adult and pediatric NAFLD, with little data regarding the relation between vitamin D and pediatric NAFLD. The aim of the present study was to examine the relation between vitamin D levels and NAFLD in children.

Methods: Clinical and histological data were used from children ages 2 to 18 years with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network studies. 25(OH) vitamin D levels were measured from serum. Data examined included demographics, anthropometrics, laboratory markers, and liver histology. Data were analyzed using 3 categories of vitamin D level: deficient (≤ 20 ng/mL), insufficient (21-29 ng/mL), and sufficient (≥ 30 ng/mL).

Results: A total of 102 children were studied. There was a high prevalence (80/102, 78%) of vitamin D deficiency or insufficiency; however, there were no significant associations between vitamin D level and the histological characteristics or severity of NAFLD. Significantly higher levels of triglycerides were found in those with vitamin D deficiency (P = 0.004), but there was no association with other features of the metabolic syndrome.

Conclusions: There is a high prevalence of vitamin D deficiency and insufficiency in children with biopsy-proven NAFLD; however, no association was found between vitamin D deficiency and the severity of disease on biopsies. This differs from adult NAFLD studies in which vitamin D deficiency correlates with histological severity, suggesting differences in the risk factors for or consequences of pediatric NAFLD.

Publication types

  • Multicenter Study
  • Observational Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • 25-Hydroxyvitamin D 2 / blood
  • Adolescent
  • Adolescent Nutritional Physiological Phenomena*
  • Biomarkers / blood
  • Biopsy
  • Calcifediol / blood
  • Child
  • Child Nutritional Physiological Phenomena*
  • Child, Preschool
  • Cross-Sectional Studies
  • Humans
  • Hypertriglyceridemia / complications
  • Liver / pathology
  • Liver Cirrhosis / etiology
  • Liver Cirrhosis / immunology
  • Non-alcoholic Fatty Liver Disease / complications*
  • Non-alcoholic Fatty Liver Disease / epidemiology
  • Non-alcoholic Fatty Liver Disease / immunology
  • Non-alcoholic Fatty Liver Disease / pathology
  • Nutritional Status*
  • Prevalence
  • Severity of Illness Index
  • United States / epidemiology
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / epidemiology


  • Biomarkers
  • 25-Hydroxyvitamin D 2
  • Calcifediol

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