Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population

J Int Med Res. 2015 Jun;43(3):326-31. doi: 10.1177/0300060514565681. Epub 2015 Feb 23.

Abstract

Objective: To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10.

Methods: Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis.

Results: Rs35975099 was in Harvey-Weinberg equilibrium in patients with migraine (n = 269) and control subjects (n = 374). There were no significant relationships between allele or genotype frequency and migraine.

Conclusion: There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.

Keywords: Migraine; TNFSF10; gene polymorphisms; susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Asian People / genetics
  • China
  • Ethnicity / genetics
  • Female
  • Gene Frequency
  • Genetic Association Studies*
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Migraine Disorders / epidemiology
  • Migraine Disorders / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • TNF-Related Apoptosis-Inducing Ligand / genetics*
  • Young Adult

Substances

  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human