Double-blind cross-over trial comparing beclomethasone dipropionate and terfenadine in perennial rhinitis

Clin Exp Allergy. 1989 Sep;19(5):569-73. doi: 10.1111/j.1365-2222.1989.tb02437.x.


Eighteen patients with perennial rhinitis were evaluated in this double-blind cross-over trial comparing beclomethasone dipropionate (BDP) aqueous nasal spray with terfenadine tablets. Both treatments were effective in reducing symptom scores but BDP was significantly better than terfenadine in relieving running nose and sneezing (P less than 0.05). BDP also had a greater effect on reducing nasal inflammation than terfenadine. Although the clinicians and patients assessed both therapies to be equi-effective, significantly more patients preferred the BDP treatment (P less than 0.003). Overall, BDP therapy proved more beneficial than terfenadine therapy in this small group of perennial rhinitis sufferers.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Beclomethasone / administration & dosage
  • Beclomethasone / therapeutic use*
  • Benzhydryl Compounds / administration & dosage
  • Benzhydryl Compounds / therapeutic use*
  • Child
  • Double-Blind Method
  • Female
  • Histamine H1 Antagonists / administration & dosage
  • Histamine H1 Antagonists / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Nebulizers and Vaporizers
  • Rhinitis, Allergic, Perennial / drug therapy*
  • Tablets
  • Terfenadine


  • Benzhydryl Compounds
  • Histamine H1 Antagonists
  • Tablets
  • Terfenadine
  • Beclomethasone