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. 2015 Feb 25:4:e04363.
doi: 10.7554/eLife.04363.

Registered report: tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

Denise Chroscinski  1 , Darryl Sampey  2 , Nimet Maherali  3 ; Reproducibility Project: Cancer Biology; Reproducibility Project Cancer Biology
Collaborators, Affiliations

Registered report: tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

Denise Chroscinski et al. Elife. .

Abstract

The Nature in 2010 (Ricci-Vitiani et al., 2010). The experiments that will be replicated are those reported in Figure 4B and Supplementary Figure 10B (Ricci-Vitiani et al., 2010), which demonstrate that glioblastoma stem-like cells can derive into endothelial cells, and can be selectively ablated to reduce tumor progression in vivo, and Supplementary Figures S10C and S10D (Ricci-Vitiani et al., 2010), which demonstrate that fully differentiated glioblastoma cells cannot form functionally relevant endothelium. The Reproducibility Project: Cancer Biology is a collaboration between the eLife.

Keywords: Reproducibility Project: Cancer Biology; cancer stem cells; developmental biology; endothelium; glioblastoma multiforme; human biology; medicine; methodology; mouse; stem cells.

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Conflict of interest statement

DC: Noble Life Sciences is a Science Exchange-associated lab.

DS: BioFactura is a Science Exchange-associated lab.

RP:CB: We disclose that Elizabeth Iorns, Fraser Tan, and Joelle Lomax are employed by and hold shares in Science Exchange Inc. The experiments presented in this manuscript will be conducted by DC at Noble Life Sciences and DS at BioFactura, which are both Science Exchange-associated laboratories.

The other authors declare that no competing interests exist.

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