GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding

J Neurosci. 2015 Feb 25;35(8):3312-8. doi: 10.1523/JNEUROSCI.3720-14.2015.


Lesions of the lateral hypothalamus (LH) cause hypophagia. However, activation of glutamatergic neurons in LH inhibits feeding. These results suggest a potential importance for other LH neurons in stimulating feeding. Our current study in mice showed that disruption of GABA release from adult LH GABAergic neurons reduced feeding. LH GABAergic neurons project extensively to the paraventricular hypothalamic nucleus (PVH), and optogenetic stimulation of GABAergic LH → PVH fibers induced monosynaptic IPSCs in PVH neurons, and potently increased feeding, which depended on GABA release. In addition, disruption of GABA-A receptors in the PVH reduced feeding. Thus, we have identified a new feeding pathway in which GABAergic projections from the LH to the PVH promote feeding.

Keywords: GABA; LH; PVH; feeding; optogenetics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Eating / physiology*
  • GABAergic Neurons / metabolism
  • GABAergic Neurons / physiology*
  • Hypothalamic Area, Lateral / cytology
  • Hypothalamic Area, Lateral / physiology*
  • Inhibitory Postsynaptic Potentials
  • Mice
  • Neural Pathways / cytology
  • Neural Pathways / physiology
  • Paraventricular Hypothalamic Nucleus / cytology
  • Paraventricular Hypothalamic Nucleus / physiology*