Abstract
The enantiomers of 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8- amine (1a) were prepared and tested for their actions on central dopamine and serotonin (5-HT) receptors. The dopaminergic effects were shown to reside in the (1)-R enantiomer. It was shown that compound 1a and its (+)-R enantiomer possess potent central 5-HT1A receptor stimulating properties.
MeSH terms
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Animals
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Brain / metabolism*
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Cell Membrane / metabolism
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Corpus Striatum / metabolism
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Dopamine Agents / metabolism*
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Indoles / metabolism*
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Isomerism
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Male
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Motor Activity / drug effects*
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Receptors, Serotonin / drug effects*
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Receptors, Serotonin / metabolism
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Reserpine / pharmacology
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Structure-Activity Relationship
Substances
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Dopamine Agents
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Indoles
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Receptors, Serotonin
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6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz(e)indol-8-amine
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Reserpine