Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties

H Wikström; B Andersson; A Svensson; L G Humber; A A Asselin; K Svensson; A Ekman; A Carlsson; I Nilsson; C Chidester

doi:10.1021/jm00130a008

Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties

J Med Chem. 1989 Oct;32(10):2273-6. doi: 10.1021/jm00130a008.

Authors

H Wikström¹, B Andersson, A Svensson, L G Humber, A A Asselin, K Svensson, A Ekman, A Carlsson, I Nilsson, C Chidester

Affiliation

¹ Department of Pharmacology, University of Göteborg, Sweden.

PMID: 2571729
DOI: 10.1021/jm00130a008

Abstract

The enantiomers of 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8- amine (1a) were prepared and tested for their actions on central dopamine and serotonin (5-HT) receptors. The dopaminergic effects were shown to reside in the (1)-R enantiomer. It was shown that compound 1a and its (+)-R enantiomer possess potent central 5-HT1A receptor stimulating properties.

MeSH terms

Animals
Brain / metabolism*
Cell Membrane / metabolism
Corpus Striatum / metabolism
Dopamine Agents / metabolism*
Indoles / metabolism*
Isomerism
Male
Motor Activity / drug effects*
Rats
Rats, Inbred Strains
Receptors, Dopamine
Receptors, Dopamine D1
Receptors, Dopamine D2
Receptors, Serotonin / drug effects*
Receptors, Serotonin / metabolism
Reserpine / pharmacology
Structure-Activity Relationship

Substances

Dopamine Agents
Indoles
Receptors, Dopamine
Receptors, Dopamine D1
Receptors, Dopamine D2
Receptors, Serotonin
6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz(e)indol-8-amine
Reserpine