Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

Nature. 1989 Oct 5;341(6241):405-9. doi: 10.1038/341405a0.


The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons originating from different segments. We report here that members of the Hox-2 cluster of murine homoeobox genes are expressed in segment-specific patterns in the developing hindbrain, with successive genes having boundaries at two-segment intervals. These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Embryonic and Fetal Development
  • Gene Expression*
  • Genes, Homeobox*
  • Mice
  • Multigene Family
  • Nucleic Acid Hybridization
  • Rhombencephalon / embryology*
  • Transcription, Genetic