Molecular chaperones: proteins essential for the biogenesis of some macromolecular structures

Trends Biochem Sci. 1989 Aug;14(8):339-42. doi: 10.1016/0968-0004(89)90168-0.


Many polypeptides can self-assemble into functional structures while others assemble only in the presence of additional proteins (molecular chaperones) which are not components of the final structure. We discuss here the effect that the recognition of the essential roles played by these proteins in assembly processes may have on the principle of spontaneous self-assembly.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chaperonins
  • Heat-Shock Proteins / metabolism
  • Nuclear Proteins / metabolism
  • Nucleoplasmins
  • Peptide Biosynthesis*
  • Phosphoproteins*
  • Proteins / metabolism*


  • Heat-Shock Proteins
  • Nuclear Proteins
  • Nucleoplasmins
  • Phosphoproteins
  • Proteins
  • Chaperonins