Transcription factors and chromatin proteins as therapeutic targets in cancer

Biochim Biophys Acta. 2015 Apr;1855(2):183-92. doi: 10.1016/j.bbcan.2015.02.002. Epub 2015 Feb 23.

Abstract

Targeting the factors that regulate gene transcription is a compelling strategy in cancer therapeutics. Traditionally, these have been considered intractable targets, but recent work has revealed novel strategies for the regulation of transcription factor activity in cancer. This review will highlight some of the emerging concepts and provide examples where agents that target transcription factors are being exploited clinically for cancer therapies.

Keywords: Cancer; Drugs; Nuclear receptors; Small molecules; Transcription factors; siRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromatin / drug effects
  • Humans
  • Molecular Targeted Therapy*
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / pathology
  • RNA, Small Interfering / therapeutic use
  • Signal Transduction / drug effects
  • Small Molecule Libraries / therapeutic use*
  • Transcription Factors / antagonists & inhibitors
  • Transcription Factors / genetics*
  • Transcription Factors / therapeutic use

Substances

  • Chromatin
  • RNA, Small Interfering
  • Small Molecule Libraries
  • Transcription Factors