The accuracy of prenatal ultrasound in determining the type of orofacial cleft

Prenat Diagn. 2015 Jul;35(7):652-5. doi: 10.1002/pd.4582. Epub 2015 Apr 6.

Abstract

Objective: The aim of this study was to assess the accuracy of prenatal transabdominal ultrasound in determining the oral cleft type.

Methods: A retrospective cohort study was performed on all consecutive cases of orofacial cleft diagnosed by prenatal ultrasound examination in the Wilhelmina Children's Hospital, a tertiary referral hospital, between January 2002 and December 2012. Prenatal findings were compared with postnatal diagnoses.

Results: A total of 134 patients were included. The mean gestational age at ultrasound examination was 24 weeks + 5 days. Prenatal diagnosis was in accordance with postnatal findings in 76.9% of the cases (103/134) with regard to the cleft type. Underestimation of the cleft occurred in 19.4% (26/134), whereas in 3.7% (5/134), the extent was overestimated. In distinguishing bilateral from unilateral clefts, no errors were made.

Conclusion: Prenatal ultrasound is accurate in assessing the types of orofacial clefts in a large majority of the cases and is completely accurate in distinguishing between unilateral and bilateral clefts. This study indicates that it is a reliable technique to assess the cleft type, which is important for counseling future parents. Although, the clinician should be aware of the fact that a cleft palate is easily missed, and subsequently, underestimation of cleft extend is frequent.

Publication types

  • Evaluation Study

MeSH terms

  • Cleft Lip / diagnostic imaging*
  • Cleft Palate / diagnostic imaging*
  • Diagnosis, Differential
  • Diagnostic Errors / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Male
  • Pregnancy
  • Retrospective Studies
  • Ultrasonography, Prenatal*