CRISPR/Cas9 and TALE: beyond cut and paste

Protein Cell. 2015 Mar;6(3):157-159. doi: 10.1007/s13238-015-0137-5.


Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CRISPR-Cas Systems / genetics*
  • Deoxyribonucleases / genetics*
  • Gene Expression Regulation*
  • Genetic Engineering*
  • Genomics / methods*
  • Humans
  • RNA Editing / genetics*


  • Deoxyribonucleases