Pine pollen inhibits cell apoptosis-related protein expression in the cerebral cortex of mice with arsenic poisoning

Yanhong Luo; Yaodong Wei; Taizhong Wang; Dongzhu Chen; Tiansheng Lu; Ruibo Wu; Keke Si

doi:10.3969/j.issn.1673-5374.2012.12.003

Pine pollen inhibits cell apoptosis-related protein expression in the cerebral cortex of mice with arsenic poisoning

Neural Regen Res. 2012 Apr 25;7(12):896-9. doi: 10.3969/j.issn.1673-5374.2012.12.003.

Authors

Yanhong Luo¹, Yaodong Wei², Taizhong Wang¹, Dongzhu Chen³, Tiansheng Lu³, Ruibo Wu³, Keke Si³

Affiliations

¹ Department of Clinical Biochemistry and Molecular Biology, Youjiang Medical College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
² Department of Biochemistry and Molecular Biology, Youjiang Medical College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
³ Grade 2008, Department of Medical Laboratory Science, Youjiang Medical College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.

PMID: 25722672
PMCID: PMC4341283
DOI: 10.3969/j.issn.1673-5374.2012.12.003

Abstract

Previous studies have demonstrated that pine pollen can inhibit cerebral cortical cell apoptosis in mice with arsenic poisoning. The present study sought to detect the influence of pine pollen on apoptosis-related proteins. Immunohistochemistry, western blotting and enzyme-linked immunosorbent assays were used to measure the levels of apoptosis-related proteins in the cerebral cortex of mice with arsenic poisoning. Results indicated that pine pollen suppressed cell apoptosis in the cerebral cortex of arsenic-poisoned mice by reducing Bax, Bcl-2 protein expression and increasing p53 protein expression.

Keywords: apoptosis; arsenic poisoning; cerebral cortex; neural regeneration; pine pollen.