For longevity, perception is everything

Vanisha Lakhina; Coleen T Murphy

doi:10.1016/j.cell.2015.02.027

For longevity, perception is everything

Cell. 2015 Feb 26;160(5):807-809. doi: 10.1016/j.cell.2015.02.027.

Authors

Vanisha Lakhina¹, Coleen T Murphy²

Affiliations

¹ Department of Molecular Biology and LSI Genomics, Princeton University, Princeton NJ 08544, USA.
² Department of Molecular Biology and LSI Genomics, Princeton University, Princeton NJ 08544, USA. Electronic address: ctmurphy@princeton.edu.

Abstract

Aging is a risk factor for chronic diseases, and identifying targets for intervention is a goal of the aging field. Burkewitz et al. now describe a mechanism that mediates the specific role for AMPK in longevity, whereby its activity in neurons modulates metabolism and mitochondrial integrity in peripheral tissues.

Publication types

Comment

MeSH terms

Animals
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / metabolism*
Catecholamines / metabolism*
Mitochondria / metabolism*
Neurons / metabolism*
Signal Transduction*
Trans-Activators / metabolism*

Substances

CRTC-1 protein, C elegans
Caenorhabditis elegans Proteins
Catecholamines
Trans-Activators

Grants and funding

R01 AG034446/AG/NIA NIH HHS/United States