Finding the right match fast

Cell. 2015 Feb 26;160(5):809-811. doi: 10.1016/j.cell.2015.02.007.


DNA recombinases face the daunting task of locating and pairing up specific sequences among millions of base pairs in a genome, all within about an hour. Qi et al. show that recombinases solve this problem by searching in 8-nt microhomology units, reducing the search space and accelerating the homology search.

Publication types

  • Comment

MeSH terms

  • Homologous Recombination*
  • Rad51 Recombinase / metabolism*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism*


  • Saccharomyces cerevisiae Proteins
  • RAD51 protein, S cerevisiae
  • Rad51 Recombinase