Fate by RNA methylation: m6A steers stem cell pluripotency

Genome Biol. 2015 Feb 22;16(1):43. doi: 10.1186/s13059-015-0609-1.

Abstract

The N 6-methyladenosine (m6A) modification of mRNA has a crucial function in regulating pluripotency in murine stem cells: it facilitates resolution of naïve pluripotency towards differentiation.

Publication types

  • Review

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / metabolism
  • Animals
  • Cell Differentiation / genetics
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism
  • Methylation
  • Mice
  • Phenotype
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / metabolism*
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism

Substances

  • RNA, Messenger
  • N-methyladenosine
  • Adenosine