Insulin resistance and hypertension: new insights

Kidney Int. 2015 Mar;87(3):497-9. doi: 10.1038/ki.2014.392.


Insulin resistance is associated with hypertension. Nakamura et al. demonstrate in rodents and humans with insulin resistance that while the stimulatory effect of insulin on glucose uptake in adipocytes, mediated via insulin receptor substrate 1 (IRS1), was severely diminished, its effect on salt reabsorption in the kidney proximal tubule, mediated via IRS2, was preserved. Compensatory hyperinsulinemia in individuals with insulin resistance may enhance salt absorption in the proximal tubule, resulting in a state of salt overload and hypertension.

Publication types

  • Comment

MeSH terms

  • Adipocytes / drug effects*
  • Animals
  • Female
  • Glucose / metabolism*
  • Humans
  • Hypertension / etiology*
  • Insulin / pharmacology*
  • Insulin Resistance / physiology*
  • Kidney Tubules, Proximal / drug effects*
  • Male
  • Sodium-Bicarbonate Symporters / drug effects*


  • Insulin
  • Sodium-Bicarbonate Symporters
  • Glucose