Available data on the effect of various trace elements on iodine metabolism and function of thyroid gland (TG) were systematized in this article. Subsequently, promising possibilities of herbal therapy in treatment and prevention of TG diseases were considered. Systemic analyis of the results of 3 independent open-label clinical studies performed in accordance with requirements of evidence-based medicine that involved herbal medicinal product Alba® (root extract of white cinquefoil) was carried out. Therapeutic options of Alba® use in various TG pathologies were presented.