The Nrf-2/ARE-HO-1 axis: An important therapeutic approach for attenuating myocardial ischemia and reperfusion injury-induced cardiac remodeling

Int J Cardiol. 2015 Apr 1:184:263-264. doi: 10.1016/j.ijcard.2015.02.073. Epub 2015 Feb 24.

Authors

Jichun Wang¹, Xiaorong Hu¹, Hong Jiang²

Affiliations

¹ Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Jiefang Road 238, Wuchang, 430060 Wuhan, PR China.
² Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Jiefang Road 238, Wuchang, 430060 Wuhan, PR China. Electronic address: jianghongwhu@163.com.

PMID: 25726904
DOI: 10.1016/j.ijcard.2015.02.073

No abstract available

Keywords: Cardiac remodeling; Heme oxygenase-1; Nuclear factor-erythroid-2 (NF-E2)-related factor 2.

Publication types

Letter
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Carboxylic Ester Hydrolases / antagonists & inhibitors
Carboxylic Ester Hydrolases / metabolism*
Heme Oxygenase-1 / antagonists & inhibitors
Heme Oxygenase-1 / metabolism*
Humans
Myocardial Ischemia / metabolism*
Myocardial Ischemia / prevention & control
Myocardial Reperfusion / methods
Myocardial Reperfusion Injury / metabolism*
Myocardial Reperfusion Injury / prevention & control
NF-E2-Related Factor 2 / antagonists & inhibitors
NF-E2-Related Factor 2 / metabolism*
Ventricular Remodeling / physiology*

Substances

NF-E2-Related Factor 2
NFE2L2 protein, human
HMOX1 protein, human
Heme Oxygenase-1
Carboxylic Ester Hydrolases
arylesterase