[P-glycoprotein: structure, physiological role and molecular mechanisms of modulation functional activity]

Usp Fiziol Nauk. 2014 Oct-Dec;45(4):89-98.
[Article in Russian]

Abstract

In the review of literature the structure, localization and a physiological role of efflux biobiotics and xenobiotics transporter - P-glycoprotein - is characterized, molecular mechanisms of induction and inhibition of its functional activity are systematized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / chemistry
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics*
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Animals
  • Gene Dosage
  • Gene Expression Regulation / genetics*
  • Humans
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic
  • Protein Transport
  • RNA Stability
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism
  • Signal Transduction
  • Xenobiotics / metabolism

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • RNA, Messenger
  • Xenobiotics