Abstract
In the review of literature the structure, localization and a physiological role of efflux biobiotics and xenobiotics transporter - P-glycoprotein - is characterized, molecular mechanisms of induction and inhibition of its functional activity are systematized.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / chemistry
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics*
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
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Animals
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Gene Dosage
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Gene Expression Regulation / genetics*
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Humans
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Polymorphism, Genetic*
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Promoter Regions, Genetic
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Protein Transport
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RNA Stability
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RNA, Messenger / genetics*
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RNA, Messenger / metabolism
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Signal Transduction
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Xenobiotics / metabolism
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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RNA, Messenger
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Xenobiotics