Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Nat Neurosci. 2015 Apr;18(4):490-2. doi: 10.1038/nn.3963. Epub 2015 Mar 2.


We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Lineage / physiology
  • Cell Proliferation / physiology*
  • Clone Cells / physiology
  • Ependyma
  • Lateral Ventricles / cytology*
  • Mice
  • Neural Stem Cells / physiology*
  • Neurogenesis / physiology*
  • Olfactory Bulb / cytology
  • Staining and Labeling