Previous research has shown that the effects of mindfulness-based interventions and increased trait mindfulness are associated with reduced stress. Further research is needed to understand the mechanisms by which mindfulness-based interventions exert their beneficial effect on decreased stress. The purpose of the present study was to examine the role of self-acceptance in the relationship between trait mindfulness and perceived stress among a sample of 132 students from Beijing, China. Results revealed that self-acceptance was found to partially mediate the relationship between mindfulness and stress. Limitations, clinical implications, and directions for future research are identified.