Biomarkers of multiorgan injury in neonatal encephalopathy

Biomark Med. 2015;9(3):267-75. doi: 10.2217/bmm.14.116.


Neonatal encephalopathy (NE) is a major contributor to neurodevelopmental deficits including cerebral palsy in term and near-term infants. The long-term neurodevelopmental outcome is difficult to predict with certainty in first few days of life. Multiorgan involvement is common but not part of the diagnostic criteria for NE. The most frequently involved organs are the heart, liver, kidneys and hematological system. Cerebral and organ involvement is associated with the release of organ specific biomarkers in cerebrospinal fluid, urine and blood. These biomarkers may have a role in the assessment of the severity of asphyxia and long-term outcome in neonates with NE.

Keywords: brain MRI; hypoxic ischemic encephalopathy; multiorgan dysfunction; neonatal encephalopathy; neurodevelopmental outcome; perinatal asphyxia; therapeutic hypothermia; thrombocytopenia; troponin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism
  • Brain Diseases / complications*
  • Brain Diseases / metabolism*
  • Hematologic Tests
  • Humans
  • Infant, Newborn
  • Organ Specificity


  • Biomarkers