Prevalence of fatigue, pain, and affective disorders in adults with duchenne muscular dystrophy and their associations with quality of life

Arch Phys Med Rehabil. 2015 Jul;96(7):1242-7. doi: 10.1016/j.apmr.2015.02.012. Epub 2015 Feb 27.


Objectives: To assess the prevalence of fatigue, pain, anxiety, and depression in adults with Duchenne muscular dystrophy (DMD), and to analyze their relationship with health-related quality of life.

Design: Cross-sectional study.

Setting: Home of participants.

Participants: Adults (N=80) with DMD.

Interventions: Not applicable.

Main outcome measures: Fatigue was assessed with the Fatigue Severity Scale; pain with 1 item of the Medical Outcomes Study 36-Item Short-Form Health Survey and by interview; and anxiety and depression by using the Hospital Anxiety and Depression Scale. Health-related quality of life was assessed using the World Health Organization Quality of Life Scale-Brief Version. Associations between these conditions and quality of life were assessed by means of univariate and multivariate logistic regression analyses.

Results: Symptoms of fatigue (40.5%), pain (73.4%), anxiety (24%), and depression (19%) were frequently found. Individuals often had multiple conditions. Fatigue was related to overall quality of life and to the quality-of-life domains of physical health and environment; anxiety was related to the psychological domain.

Conclusions: Fatigue, pain, anxiety, and depression, potentially treatable symptoms, occur frequently in adults with DMD and significantly influence health-related quality of life.

Keywords: Adult; Fatigue; Mood disorders; Muscular dystrophy, Duchenne; Pain; Quality of life; Rehabilitation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anxiety / epidemiology
  • Anxiety / psychology*
  • Cross-Sectional Studies
  • Depression / epidemiology
  • Depression / psychology*
  • Fatigue / epidemiology
  • Fatigue / psychology*
  • Female
  • Health Status
  • Humans
  • Male
  • Muscular Dystrophy, Duchenne / epidemiology
  • Muscular Dystrophy, Duchenne / psychology*
  • Pain / epidemiology
  • Pain / psychology*
  • Prevalence
  • Psychiatric Status Rating Scales
  • Quality of Life*
  • Severity of Illness Index