On-demand d-modafinil may be an effective treatment option for lifelong premature ejaculation: a case report

Andrologia. 2016 Feb;48(1):121-2. doi: 10.1111/and.12410. Epub 2015 Mar 4.


Premature ejaculation (PE) is considered to be the most common form of male sexual dysfunction. Given that acute oral administration of d-isomer of modafinil (d-modafinil) can extend the latency to ejaculation in rats without suppressing sexual behaviour, the effects of on-demand d-modafinil treatment were examined on a 30-year-old male patient with lifelong PE. The patient was instructed to take d-modafinil 100 mg 3 h prior to the sexual relation for four times and was invited for a control visit. The patient was re-evaluated 2 weeks later. He reported that his IELT increased to 15 min. He reported heartburn and insomnia when he used d-modafinil for the first time; however, these symptoms were transient and did not recur after the initial dose. Overall, he reported considerable improvement and noted that he feels much better with the treatment. Based on this limited data, on-demand d-modafinil seems to be an effective treatment for men with lifelong PE. The side effects were transient and mild in the reported case. Further randomised clinical trials are necessary to elucidate the therapeutic concept of this drug in patients with lifelong PE.

Keywords: lifelong; modafinil; premature ejaculation; treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Benzhydryl Compounds / therapeutic use*
  • Humans
  • Male
  • Modafinil
  • Premature Ejaculation / drug therapy*
  • Treatment Outcome
  • Wakefulness-Promoting Agents / therapeutic use*


  • Benzhydryl Compounds
  • Wakefulness-Promoting Agents
  • Modafinil