Subversive bacteria reveal new tricks in their cytoskeleton-hijacking arsenal

Nat Struct Mol Biol. 2015 Mar;22(3):178-9. doi: 10.1038/nsmb.2976.

Abstract

During infection, pathogenic Yersinia species secrete the antiphagocytic factor YopO (or YpkA), which contains a kinase domain and a Rho GTPase guanine nucleotide dissociation inhibitor (GDI) domain. The structure of YopO in complex with actin and biochemical analyses reveal the mechanism by which YopO uses actin to activate its kinase domain and recruit, phosphorylate and deactivate actin-assembly factors implicated in phagocytic clearance of the bacterium.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Actins / chemistry*
  • Bacterial Outer Membrane Proteins / chemistry*
  • Bacterial Proteins / chemistry*
  • Models, Molecular*
  • Protein-Serine-Threonine Kinases / chemistry*

Substances

  • Actins
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • YopO protein, Yersinia enterocolitica
  • Protein-Serine-Threonine Kinases