Metabolic switches linked to pluripotency and embryonic stem cell differentiation

Cell Metab. 2015 Mar 3;21(3):349-50. doi: 10.1016/j.cmet.2015.02.011.


Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Acetyl Coenzyme A / metabolism*
  • Animals
  • Cell Differentiation / physiology*
  • Embryonic Stem Cells / metabolism*
  • Embryonic Stem Cells / physiology*
  • Glycolysis / physiology*
  • Histones / metabolism*
  • Humans


  • Histones
  • Acetyl Coenzyme A