A mitochondrially encoded hormone ameliorates obesity and insulin resistance

Kim Zarse; Michael Ristow

doi:10.1016/j.cmet.2015.02.013

A mitochondrially encoded hormone ameliorates obesity and insulin resistance

Cell Metab. 2015 Mar 3;21(3):355-6. doi: 10.1016/j.cmet.2015.02.013.

Authors

Kim Zarse¹, Michael Ristow²

Affiliations

¹ Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH), 8603 Zurich, Switzerland.
² Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH), 8603 Zurich, Switzerland. Electronic address: michael-ristow@ethz.ch.

PMID: 25738453
DOI: 10.1016/j.cmet.2015.02.013

Abstract

MOTS-c, a mitochondrially encoded open reading frame-derived peptide recently discovered by Lee et al. 2015 (this issue of Cell Metabolism) promotes biosynthesis of an endogenous AMP analog, AICAR. As AICAR activates AMPK, the discovery of MOTS-c offers an unexpected therapeutic option to be exploited toward the prevention of type 2 diabetes and delaying of the aging processes.

Publication types

Comment

MeSH terms

Animals
Homeostasis / physiology*
Humans
Insulin Resistance / physiology*
Male
Mitochondria / metabolism*
Obesity / metabolism*
Peptides / metabolism*

Substances

Peptides