Lewy bodies in tyrosine hydroxylase-synthesizing neurons of the human cerebral cortex

Neurosci Lett. 1989 Nov 20;106(1-2):49-54. doi: 10.1016/0304-3940(89)90200-0.


A population of neurons situated in the human cerebral neocortex contains mRNA coding for tyrosine hydroxylase, the key enzyme for catecholamine biosynthesis. Phosphorylated neurofilament-containing cytoplasmic inclusions occur in these neurons in diffuse Lewy body disease, indicating a tendency for selective involvement that is shared with subcortical catecholamine-containing neurons. These findings are relevant to the pathophysiology of several neurologic and psychiatric illnesses in which the monoamine-containing neurons of the neocortex may participate.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antibodies, Monoclonal
  • Cerebral Cortex / enzymology*
  • Dementia / metabolism
  • Dementia / pathology*
  • Humans
  • Immunohistochemistry
  • Inclusion Bodies / metabolism
  • Inclusion Bodies / pathology*
  • Intermediate Filament Proteins / metabolism*
  • Neurofilament Proteins
  • Tyrosine 3-Monooxygenase / metabolism*


  • Antibodies, Monoclonal
  • Intermediate Filament Proteins
  • Neurofilament Proteins
  • Tyrosine 3-Monooxygenase