Oxidative calcium release from catechol

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1453-4. doi: 10.1016/j.bmcl.2015.02.036. Epub 2015 Feb 23.

Abstract

Oxidation of 4-methylcatechol previously exposed to aqueous calcium chloride was shown by ion chromatography to be associated with release of calcium ions. The catechol was oxidised to the corresponding orthoquinone by the use of tyrosinase from Agaricus bisporus. The oxidative release of calcium from the catechol is ascribed to the diminution of the available hydroxyl functions able to act as chelating groups. Our results suggest that the redox status of melanin may regulate calcium binding and influence calcium levels in pigmented cells.

Keywords: Calcium; Melanin; Oxidation; Photoprotection; Tyrosinase.

MeSH terms

  • Agaricus / enzymology
  • Calcium / chemistry
  • Calcium / metabolism*
  • Catechols / chemistry
  • Catechols / metabolism*
  • Monophenol Monooxygenase / metabolism
  • Oxidation-Reduction
  • Quinones / chemistry
  • Quinones / metabolism

Substances

  • Catechols
  • Quinones
  • Monophenol Monooxygenase
  • catechol
  • Calcium