Evolution of insecticide resistance diagnostics in malaria vectors

Trans R Soc Trop Med Hyg. 2015 May;109(5):291-3. doi: 10.1093/trstmh/trv017. Epub 2015 Mar 3.


Malaria control is reliant upon effective, programmatic-scale, anti-vector interventions. The widespread distribution of pyrethroid-treated bednets in sub-Saharan Africa has been a driver of morbidity and mortality reductions over the last decade. Unfortunately resistance to insecticides, and to pyrethroids in particular, is increasingly common in Anopheles malaria vectors, and is a major threat to continued control and future elimination. Here we argue that current methods to diagnose resistance often have limited utility and should be augmented or even partially replaced by wider application of DNA markers.

Keywords: Anopheles; DNA markers; Diagnostics; Insecticide resistance.

MeSH terms

  • Animals
  • Anopheles / drug effects
  • Anopheles / genetics*
  • Biological Assay
  • Humans
  • Insecticide Resistance / drug effects
  • Insecticide Resistance / genetics*
  • Insecticides / pharmacology*
  • Malaria / prevention & control*
  • Malaria / transmission
  • Mosquito Control / methods
  • Mutation
  • Pyrethrins / pharmacology*


  • Insecticides
  • Pyrethrins