Iodoarene-catalyzed cyclizations of unsaturated amides

Org Lett. 2015 Mar 20;17(6):1453-6. doi: 10.1021/acs.orglett.5b00333. Epub 2015 Mar 5.

Abstract

The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route. Preliminary data from the use of chiral iodoarenes as precatalysts show that enantiocontrol is feasible.