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. 2015 Feb 26;20(8):21043.
doi: 10.2807/1560-7917.es2015.20.8.21043.

Trivalent Inactivated Seasonal Influenza Vaccine Effectiveness for the Prevention of Laboratory-Confirmed Influenza in a Scottish Population 2000 to 2009

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Trivalent Inactivated Seasonal Influenza Vaccine Effectiveness for the Prevention of Laboratory-Confirmed Influenza in a Scottish Population 2000 to 2009

C R Simpson et al. Euro Surveill. .
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Abstract

To evaluate seasonal trivalent inactivated influenza vaccine effectiveness (VE) in Scotland, we performed a Scotland-wide linkage of patient-level primary care, hospital and virological swab data from 3,323 swabs (pooling data over nine influenza seasons: 2000/01 to 2008/09). We estimated the VE for reducing realtime RT-PCR-confirmed influenza using a test-negative study design. Vaccination was associated with a 57% (95% confidence interval (CI): 31–73) reduction in the risk of PCR-confirmed influenza. VE was 60% (95% CI:22–79) for patients younger than 65 years and clinically at risk of serious complications from influenza, and 19% (95% CI: −104 to 68) for any individual 65 years and older. Vaccination was associated with substantial, sustained reductions in laboratory-confirmed influenza in the general population and younger patients in clinical at-risk groups.

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