Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

Br J Cancer. 2015 Mar 31;112(7):1251-6. doi: 10.1038/bjc.2015.83.


Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma.

Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.

Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.

Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Endocrine Disruptors / poisoning*
  • Europe / epidemiology
  • Female
  • Humans
  • Incidence
  • Lymphoma / chemically induced
  • Lymphoma / epidemiology*
  • Male
  • Occupational Diseases / chemically induced
  • Occupational Diseases / epidemiology*
  • Occupational Exposure / adverse effects
  • Occupational Exposure / statistics & numerical data*
  • Risk Factors
  • Sex Factors


  • Endocrine Disruptors