Synthesis, structural and antioxidant studies of some novel N-ethyl phthalimide esters

PLoS One. 2015 Mar 5;10(3):e0119440. doi: 10.1371/journal.pone.0119440. eCollection 2015.

Abstract

A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemical synthesis*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Esters / chemical synthesis*
  • Esters / chemistry
  • Esters / pharmacology
  • Free Radical Scavengers / chemistry
  • Molecular Structure
  • Oxidation-Reduction
  • Phthalimides / chemical synthesis*
  • Phthalimides / chemistry
  • Phthalimides / pharmacology
  • X-Ray Diffraction

Substances

  • Antioxidants
  • Esters
  • Free Radical Scavengers
  • Phthalimides

Grants and funding

CSCK thanks Universiti Sains Malaysia (USM) for a postdoctoral research fellowship. WSL thanks Malaysian Government for MyBrain15 (MyPhD) scholarship. CKQ thanks Malaysian Government and USM for Fundamental Research Grant Scheme (FRGS) (203/PFIZIK/6711411). The authors extend their appreciation to The Deanship of Scientific Research at King Saud University for the funding the work through the research group project No. RGP VPP-207. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.