Genomic imprinting in hereditary glomus tumours: evidence for new genetic theory

Lancet. 1989 Dec 2;2(8675):1291-4. doi: 10.1016/s0140-6736(89)91908-9.


A study based on fifteen pedigrees showed that familial glomus tumours are inherited almost exclusively via the paternal line, a finding inconsistent with autosomal dominant transmission. The results can be explained in terms of the genomic imprinting hypothesis--the maternally derived gene is inactivated during female oogenesis and can be reactivated only during spermatogenesis. Genomic imprinting may have considerable implications for genetic counselling with respect to glomus tumours and also for the understanding of other hereditary diseases.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Glomus Tumor / genetics*
  • Head and Neck Neoplasms / genetics*
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Sex Factors