Alzheimer's 100th anniversary of death and his contribution to a better understanding of Senile dementia

Arq Neuropsiquiatr. 2015 Feb;73(2):159-62. doi: 10.1590/0004-282X20140207.


Initially the trajectory of the historical forerunners and conceptions of senile dementia are briefly presented, being highlighted the name of Alois Alzheimer who provided clinical and neuropathological indicators to differentiate a group of patients with Senile dementia. Alzheimer's examination of Auguste D's case, studied by him with Bielschowsky's silver impregnation technique, permitted to identify a pathological marker, the intraneuronal neurofibrillary tangles, characterizing a new disease later named after him by Kraepelin - Alzheimer's disease. Over the time this disorder became one of the most important degenerative dementing disease, reaching nowadays a status that may be considered as epidemic.

Publication types

  • Biography
  • Historical Article
  • Portrait

MeSH terms

  • Alzheimer Disease / history*
  • Alzheimer Disease / pathology*
  • Anniversaries and Special Events
  • Biomarkers
  • Brain / pathology
  • Diterpenes
  • History, 19th Century
  • History, 20th Century


  • Biomarkers
  • Diterpenes
  • bielschowskysin

Personal name as subject

  • Alois Alzheimer