Is antigenic sin always "original?" Re-examining the evidence regarding circulation of a human H1 influenza virus immediately prior to the 1918 Spanish flu

Alain Gagnon; J Enrique Acosta; Joaquin Madrenas; Matthew S Miller

doi:10.1371/journal.ppat.1004615

Is antigenic sin always "original?" Re-examining the evidence regarding circulation of a human H1 influenza virus immediately prior to the 1918 Spanish flu

PLoS Pathog. 2015 Mar 5;11(3):e1004615. doi: 10.1371/journal.ppat.1004615. eCollection 2015 Mar.

Authors

Alain Gagnon¹, J Enrique Acosta¹, Joaquin Madrenas², Matthew S Miller³

Affiliations

¹ Département de Démographie, Université de Montréal, Montreal, Quebec, Canada.
² Department of Microbiology and Immunology and Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec, Canada.
³ Department of Biochemistry and Biomedical Sciences, Institute for Infectious Diseases Research, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.

No abstract available

Publication types

Historical Article
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
History, 19th Century
History, 20th Century
Humans
Influenza A Virus, H1N1 Subtype / genetics*
Influenza A Virus, H1N1 Subtype / immunology*
Influenza Pandemic, 1918-1919 / history
Male
Phylogeny*
Russia (Pre-1917)

Grants and funding

This work was supported by the Social Science and Humanity and Research council of Canada (http://www.sshrc-crsh.gc.ca/home-accueil-eng.aspx) (AG) and the Canadian Institutes of Health Research (http://www.cihr-irsc.gc.ca/e/193.html) (AG, MSM, and JM). JM holds a Tier I Canada Research Chair in Human Immunology. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.