Bone muscle interactions and vitamin D

Bone. 2015 Nov;80:89-94. doi: 10.1016/j.bone.2015.02.029. Epub 2015 Mar 6.


Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe vitamin D deficiency or mutations of the vitamin D receptor develop generalized atrophy of muscle and bone, suggesting coordinated effects of vitamin D in musculoskeletal physiology. At a mechanistic level, vitamin D exerts wide-ranging effects in muscle and bone calcium handling, differentiation and development. Vitamin D also modulates muscle and bone-derived hormones, facilitating cross-talk between these tissues. In this review, we discuss emerging evidence that vitamin D regulates bone and muscle in a direct, integrated fashion, positioning the vitamin D pathway as a potential therapeutic target for musculoskeletal diseases. This article is part of a Special Issue entitled "Muscle Bone Interactions".

Keywords: Bone; Cross-talk; Muscle; Osteoporosis; Sarcopenia; Vitamin D.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone and Bones / metabolism*
  • Humans
  • Muscle, Skeletal / metabolism*
  • Osteoporosis / metabolism
  • Sarcopenia / metabolism
  • Vitamin D / metabolism*


  • Vitamin D