TCGF III/P40 is produced by naive murine CD4+ T cells but is not a general T cell growth factor

Eur J Immunol. 1989 Nov;19(11):2167-70. doi: 10.1002/eji.1830191130.


Several antigen-specific T cell lines were found to secrete a lymphokine upon activation by antigen or lectin that was provisionally termed T cell growth factor III (TCGF III) because it induced the proliferation of a CD4+ T cell clone independently from IL2 and IL4. Amino acid sequence analysis (and the functional properties of TCGF III) revealed that TCGF III was identical with a recently identified lymphokine termed P40. TCGF III/P40 was not only produced by long-term cultured T cell lines but also upon stimulation of freshly isolated Mlsa-reactive T cells. In addition, naive CD4+ T cells secreted TCGF III/P40 upon activation by lectin or allo-major histocompatibility complex structures. However, in spite of its growth-promoting activity for a CD4+ T cell clone this lymphokine does not appear to function as a general growth factor for T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • CD4-Positive T-Lymphocytes / physiology*
  • Cell Line
  • Glycoproteins / genetics
  • Glycoproteins / physiology*
  • Growth Substances / genetics
  • Growth Substances / physiology*
  • Interleukin-2 / pharmacology
  • Interleukin-4 / pharmacology
  • Interleukin-9
  • Lymphocyte Culture Test, Mixed
  • Lymphokines / physiology*
  • Mice
  • Mice, Inbred Strains
  • Molecular Sequence Data
  • T-Lymphocytes, Helper-Inducer / immunology


  • Glycoproteins
  • Growth Substances
  • Interleukin-2
  • Interleukin-9
  • Lymphokines
  • Interleukin-4