The efficacy and tolerability of nifedipine (NIF) and nisoldipine (NIS) both alone and combined with a beta-blocker in patients with essential hypertension: a multicenter, parallel-group study

J Clin Pharmacol. 1989 Nov;29(11):1013-6. doi: 10.1002/j.1552-4604.1989.tb03271.x.

Abstract

We have assessed the efficacy and tolerance of Nifedipine twice daily and Nisoldipine once daily, both alone and in combination with a beta-blocker in 171 essential hypertensives in a randomized parallel comparison fashion. Both drugs were equally effective in lowering blood pressure: 72.6% of the subjects on Nisoldipine and 80.5% of those on Nifedipine reached a supine diastolic blood pressure less than or equal to 90 mmHg. Spontaneously reported side effects were frequent but no biochemical, hematological or electrocardiographic abnormalities were detected.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • Adult
  • Aged
  • Blood Pressure / drug effects
  • Body Weight / drug effects
  • Double-Blind Method
  • Drug Therapy, Combination
  • Drug Tolerance
  • Female
  • Heart Rate / drug effects
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Nifedipine / administration & dosage
  • Nifedipine / adverse effects
  • Nifedipine / therapeutic use*
  • Nisoldipine / administration & dosage
  • Nisoldipine / adverse effects
  • Nisoldipine / therapeutic use*
  • Randomized Controlled Trials as Topic

Substances

  • Adrenergic beta-Antagonists
  • Nisoldipine
  • Nifedipine