Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation

Annu Rev Biochem. 2015:84:131-64. doi: 10.1146/annurev-biochem-060614-034115. Epub 2015 Feb 26.


Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. Lamins bind to a growing number of nuclear protein complexes and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific functions. The lamin-based complexes and their specific functions also provide insights into possible disease mechanisms for human laminopathies, ranging from muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical Werner syndromes.

Keywords: chromatin; intermediate filament; laminopathies; lamins; nuclear envelope; nuclear mechanics; nuclear organization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / chemistry
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism*
  • Chromatin / chemistry
  • Chromatin / metabolism
  • Gene Expression Regulation
  • Humans
  • Lamins / chemistry
  • Lamins / genetics
  • Lamins / metabolism*
  • Progeria / pathology


  • Chromatin
  • Lamins