Hypertension and left ventricular diastolic function

Mayo Clin Proc. 1989 Dec;64(12):1521-32. doi: 10.1016/s0025-6196(12)65708-5.


In recent years, there has been increased recognition of the relative importance of abnormalities of diastolic function in patients with essential hypertension. Indeed, diastolic dysfunction may be the earliest indicator of hypertensive heart disease. In this article, the mechanisms governing normal ventricular relaxation and the factors that may cause diastolic dysfunction are reviewed. Noninvasive clinical methods, particularly Doppler echocardiography and radionuclide angiography, for determination of diastolic function are outlined, and the limited experience in the management of hypertensive patients with abnormalities of diastolic function is discussed. When congestive heart failure develops in a patient with hypertension, it is especially important to determine whether it is due primarily to systolic or to diastolic left ventricular dysfunction.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Blood Pressure* / drug effects
  • Calcium Channel Blockers / therapeutic use
  • Diastole / drug effects
  • Echocardiography
  • Heart Failure / complications
  • Heart Failure / diagnosis
  • Heart Failure / drug therapy
  • Heart Failure / physiopathology
  • Heart Rate / drug effects
  • Heart Ventricles / diagnostic imaging
  • Heart Ventricles / physiopathology
  • Humans
  • Hypertension / complications
  • Hypertension / diagnostic imaging
  • Hypertension / drug therapy
  • Hypertension / physiopathology*
  • Radionuclide Imaging
  • Sodium Pertechnetate Tc 99m
  • Stroke Volume / drug effects


  • Adrenergic beta-Antagonists
  • Calcium Channel Blockers
  • Sodium Pertechnetate Tc 99m