Does the antenatal detection of fetal growth restriction (FGR) have a prognostic value for mortality and short-term morbidity for very preterm infants? Results from the MOSAIC cohort

J Matern Fetal Neonatal Med. 2016;29(4):596-601. doi: 10.3109/14767058.2015.1012062. Epub 2015 Mar 9.


Objective: We investigated the impact of antenatal diagnosis of fetal growth restriction (FGR) on the risks of mortality and morbidity for very preterm infants given actual birthweight percentiles.

Methods: Data on 4608 live born infants 24-31 weeks of gestational age (GA) in 10 European regions in 2003 were used to compare in-hospital mortality, bronchopulmonary dysplasia (BPD) and severe neurological morbidity by birthweight percentiles and antenatal diagnosis of FGR. Other covariates were GA, sex, multiplicity, maternal complications, antenatal corticosteroids, birth in a level III center and region.

Results: Sixteen percent (n = 728) of all infants and 72%, 30% and 6%, respectively, of those with birthweight percentiles <10th, 10th-24th and ≥25th had an antenatal diagnosis of FGR. After adjustment for clinical factors, antenatal diagnosis of FGR was not associated with mortality for infants with a birthweight ≥10th percentile (OR [95% CI]: 0.9 [0.5-1.9] and 1.0 [0.6-1.8] for birthweights between the 10th-24th percentile and ≥25th percentile, respectively), but infants with a birthweight <10th percentile had higher mortality (OR [95% CI]: 2.4 [1.0-5.8]). No association was observed at any birthweight percentile with BPD or severe neurological morbidity.

Conclusion: Antenatal diagnosis of FGR did not influence risks of mortality or morbidity when birthweight was ≥10th percentile; however, mortality risk was higher in antenatally detected infants with birthweight below the <10th percentile.

Keywords: Birthweight percentile; bronchopulmonary dysplasia; fetal growth restriction; in-hospital mortality; preterm infants; severe neurological morbidity.

MeSH terms

  • Cohort Studies
  • Europe / epidemiology
  • Female
  • Fetal Growth Retardation / diagnosis*
  • Hospital Mortality*
  • Humans
  • Infant
  • Infant Mortality*
  • Infant, Newborn
  • Infant, Premature*
  • Infant, Very Low Birth Weight
  • Male
  • Pregnancy
  • Prenatal Diagnosis*
  • Prognosis