Head-to-head Randomized Trials Are Mostly Industry Sponsored and Almost Always Favor the Industry Sponsor

J Clin Epidemiol. 2015 Jul;68(7):811-20. doi: 10.1016/j.jclinepi.2014.12.016. Epub 2015 Feb 7.

Abstract

Objectives: To map the current status of head-to-head comparative randomized evidence and to assess whether funding may impact on trial design and results.

Study design and setting: From a 50% random sample of the randomized controlled trials (RCTs) published in journals indexed in PubMed during 2011, we selected the trials with ≥ 100 participants, evaluating the efficacy and safety of drugs, biologics, and medical devices through a head-to-head comparison.

Results: We analyzed 319 trials. Overall, 238,386 of the 289,718 randomized subjects (82.3%) were included in the 182 trials funded by companies. Of the 182 industry-sponsored trials, only 23 had two industry sponsors and only three involved truly antagonistic comparisons. Industry-sponsored trials were larger, more commonly registered, used more frequently noninferiority/equivalence designs, had higher citation impact, and were more likely to have "favorable" results (superiority or noninferiority/equivalence for the experimental treatment) than nonindustry-sponsored trials. Industry funding [odds ratio (OR) 2.8; 95% confidence interval (CI): 1.6, 4.7] and noninferiority/equivalence designs (OR 3.2; 95% CI: 1.5, 6.6), but not sample size, were strongly associated with "favorable" findings. Fifty-five of the 57 (96.5%) industry-funded noninferiority/equivalence trials got desirable "favorable" results.

Conclusion: The literature of head-to-head RCTs is dominated by the industry. Industry-sponsored comparative assessments systematically yield favorable results for the sponsors, even more so when noninferiority designs are involved.

Keywords: Conflict of interest; Cross-sectional study; Head-to-head comparison; Industry sponsorship; Noninferiority trials; Randomized controlled trials.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Asia
  • Conflict of Interest
  • Drug Industry / economics*
  • Empirical Research
  • Europe
  • Internationality
  • Patient Selection
  • Randomized Controlled Trials as Topic / economics*
  • Research Design
  • Research Support as Topic / methods
  • Research Support as Topic / organization & administration
  • Research Support as Topic / statistics & numerical data*
  • United States