Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated

Neurosci Lett. 2015 Apr 10;592:54-8. doi: 10.1016/j.neulet.2015.03.005. Epub 2015 Mar 4.


Emerging studies link vascular risk factors and cerebrovascular health to the prevalence and rates of progression in Alzheimer's disease (AD). The brain's ability to maintain constant blood flow across a range of cerebral perfusion pressures, or autoregulation, may both promote and result from small vessel cerebrovascular disease and AD-related amyloid pathology. Here, we examined the relationship among cerebral autoregulation, small vessel cerebrovascular disease, and amyloid deposition in 14 non-demented older adults. Reduced cerebral autoregulation, was associated with increased amyloid deposition and increased white matter hyperintensity volume, which, in turn were positively associated with each other. For the first time in humans, we demonstrate an interrelationship among AD pathology, small vessel cerebrovascular disease, and cerebral autoregulation. Vascular factors and AD pathology are not independent but rather appear to interact.

Keywords: Alzheimer; Amyloid; Cerebral autoregulation; White matter hyperintensities; ’s disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amyloid / metabolism*
  • Brain / blood supply
  • Brain / metabolism*
  • Brain / pathology*
  • Cerebrovascular Disorders / metabolism*
  • Cerebrovascular Disorders / pathology*
  • Female
  • Hemodynamics
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Positron-Emission Tomography
  • White Matter / pathology*


  • Amyloid