MicroRNAs-mediated cell fate in triple negative breast cancers

Xinbing Sui; Xian Wang; Weidong Han; Da Li; Yinghua Xu; Fang Lou; Jichun Zhou; Xidong Gu; Jing Zhu; Cheng Zhang; Hongming Pan

doi:10.1016/j.canlet.2015.02.048

MicroRNAs-mediated cell fate in triple negative breast cancers

Cancer Lett. 2015 May 28;361(1):8-12. doi: 10.1016/j.canlet.2015.02.048. Epub 2015 Mar 3.

Authors

Xinbing Sui¹, Xian Wang¹, Weidong Han¹, Da Li¹, Yinghua Xu², Fang Lou², Jichun Zhou³, Xidong Gu⁴, Jing Zhu⁵, Cheng Zhang⁶, Hongming Pan⁷

Affiliations

¹ Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China; Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China.
² Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
³ Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
⁴ Department of Breast Surgery, The First affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
⁵ Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
⁶ Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
⁷ Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China; Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China. Electronic address: drpanhm@aliyun.com.

PMID: 25748387
DOI: 10.1016/j.canlet.2015.02.048

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that function as major modulators of posttranscriptional protein-coding gene expression in diverse biological processes including cell survival, cell cycle arrest, senescence, autophagy, and differentiation. The control of miRNAs plays an important role in cancer initiation and metastasis. Triple negative breast cancer (TNBC) is a distinct breast cancer subtype, which is defined by the absence of estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2/neu). Due to its high recurrence rate and poor prognosis, TNBC represents a challenge for breast cancer therapy. In recent years, a large number of microRNAs have been identified to play a crucial role in TNBC and some of them were found to be correlated with worse prognosis of TNBC. Thus, understanding the novel function of miRNAs may allow us to develop promising therapeutic targets for the treatment of TNBC patients.

Keywords: Cell fate; MicroRNA; Triple negative breast cancer.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Female
Gene Expression Regulation, Neoplastic*
Humans
MicroRNAs / genetics*
Triple Negative Breast Neoplasms / genetics*
Triple Negative Breast Neoplasms / pathology*

Substances

MicroRNAs