Acute graft-versus-host disease, invasive aspergillosis and Clostridium difficile colitis after peripheral blood stem cell transplantation: A complex network of causalities and a challenge for prevention

Anaerobe. 2015 Jun:33:98-100. doi: 10.1016/j.anaerobe.2015.02.007. Epub 2015 Mar 5.

Abstract

Graft-versus-host disease (GVHD) is a known risk factor for invasive aspergillosis (IA), but remains poorly studied in relation to Clostridium difficile infection (CDI). We report a case of a 58-years-old patient who developed an IA within a protected room, CDI and GVHD after allogeneic allogeneic peripheral blood stem cell transplantation (PBSCT). Factors associated with this complex condition in patients receiving allogeneic PBSCT need to be identified.

Keywords: Bone marrow transplant; Clostridium difficile infection; Environmental transmission; Graft-versus-host disease; Invasive aspergillosis; Nosocomial.

Publication types

  • Case Reports

MeSH terms

  • Anti-Infective Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols
  • Aspergillosis / diagnosis
  • Aspergillosis / drug therapy
  • Aspergillosis / etiology*
  • Enterocolitis, Pseudomembranous / diagnosis
  • Enterocolitis, Pseudomembranous / drug therapy
  • Enterocolitis, Pseudomembranous / etiology*
  • Fatal Outcome
  • Graft vs Host Disease / diagnosis
  • Graft vs Host Disease / etiology*
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Male
  • Middle Aged
  • Peripheral Blood Stem Cell Transplantation / adverse effects*
  • Transplantation, Homologous

Substances

  • Anti-Infective Agents