From histones to ribosomes: a chromatin regulator tangoes with translation

Cancer Discov. 2015 Mar;5(3):228-30. doi: 10.1158/2159-8290.CD-15-0073.


Histone lysine methylation is a critical regulator of chromatin-templated processes such as gene transcription and DNA repair, and is dynamically controlled by enzymes that write and erase this posttranslational modification. Although histone methylation has been well studied, the functions of nonhistone lysine methylation and its regulatory enzymes, particularly outside the nucleus, are poorly defined. In this issue of Cancer Discovery, Van Rechem and colleagues shed light on a new role for the lysine demethylase KDM4A as a regulator of protein translation and identify a single-nucleotide polymorphism in the KDM4A gene as a candidate biomarker for mTOR inhibitor therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Drug Resistance, Neoplasm / genetics*
  • Humans
  • Jumonji Domain-Containing Histone Demethylases / genetics*
  • Jumonji Domain-Containing Histone Demethylases / metabolism*
  • Lysine / genetics*
  • Lysine / metabolism*
  • Open Reading Frames*
  • Polymorphism, Single Nucleotide*
  • Protein Biosynthesis*
  • Protein Kinase Inhibitors / pharmacology*
  • TOR Serine-Threonine Kinases / antagonists & inhibitors*


  • Antineoplastic Agents
  • Protein Kinase Inhibitors
  • Jumonji Domain-Containing Histone Demethylases
  • KDM4A protein, human
  • TOR Serine-Threonine Kinases
  • Lysine